Cardiac Troponin 1 rapid 15 minute test

The NADAL® Cardiac Troponin I Test is a single-level chromatographic immunoassay for the rapid and qualitative detection of human cardiac Troponin I in whole blood, serum or plasma. It is used as an aid in the diagnosis of myocardial infarction (MI).

Introduction and Clinical Significances

Cardiac Troponin (cTnl) is a protein found in the cardiac muscle with a molecular weight of 22.5 kDa1. Troponin I is part of a three sub-unit complex, comprising of Troponin T and Troponin C. Along with Tropomyosin, this structural complex forms the main component that regulates the calcium sensitive ATPa Actomyosin in striated skeletal and cardiac muscle2. After cardiac injury occurs, Troponin I is released into the blood 4-6 hours after the onset of pain. The release pattern of cardiac Tnl is similar to CK-MB, but while CK-MB levels return to normal after 72 hours, Troponin I remains elevated for 6-10 days, thus providing a longer window of detection for cardiac injury. The high specificity of cTnl measurements for the identification of myocardial damage has been demonstrated in conditions such as surgery, after marathon runs and blunt chest trauma3. cTnl release has also been documented in cardiac conditions other than acute myocardial infarction (AMI) such as unstable angina, congestive heart failure, and ischemic damage due to coronary artery bypass surgery4. Because of its high specificity and sensitivity in the myocardial tissue, Troponin I has recently become the most preferred biomarker for myocardial infarction5.

The NADAL® Troponin I Test is a simple test that utilises a combination of particle conjugated cTnl specific antibodies and captor reagents to selectively detect cTnl in whole blood, serum or plasma. The minimum detection level is 1 ng/mL.